This book will cover (1) current medical top down methodologies and why they do not suit the patient or payer. (2) Aggregation of disparate data sources. Addressing the known and unknown challenges we face in personalized medicine. How will the careers of tomorrow be defined by this shift in medicine. (3) Advanced analytical resources and current technical toolsets. What we have versus what is available and how these items will shape the future. The face of data science and playbooks for biomedical science are being designed as we read. How will they shape medicine, politics and education (research)? (4) Bioinformatics as a service, why we are closing in on this far away objective and how we now can define what it truly "is" versus the previous vendor definitions that have failed against the test of time. And (5) The untapped future of IOT and the deluge of millions of medical devices and personal health devices. In addition, this book contains actual use cases in every chapter and well delineated examples.