This book overviews the state-of-the-art methods in bioorganic chemistry, addressing both synthetic and enzymologic aspects. It opens with an historical look at chemistry and biology, and how they have converged in recent years to become bioorganic chemistry, followed by a review of biocatalysis principles. Subsequent chapters deal with utilizing enzymes as catalysts or the modification of enzymes. These include restrosynthesis, single step conversions, multistep reactions, and modification strategies. Designed for use as a class text, the book features textboxes to highlight particular issues and applications along with end-of-chapter questions / answers for students to test progress and understanding. In addition, as an online ancillary for adopting professors, the authors offer high-quality renditions of the illustrations for use in course lectures.