Migraines impact the lives of a significant portion of world’s population with severe pain, nausea, and visual impairment. Great strides have been made in uncovering the biological mechanisms that lead to the development of migraine headaches. Neurobiological Basis of Migraine provides readers with a deep understanding of the molecular mechanisms of migraine and provides valuable insight into translating these findings into novel treatment and preventative options.
Neurobiological Basis of Migraine provides focused, but broad-ranging coverage on the neurobiological mechanisms of migraine headaches. First, the pathways and networks mediating the headache, underlying physiological mechanisms, characteristics of visceral pain and concept of dural neurogenic inflammation are introduced. This background paves the way for understanding mechanisms sustaining the head pain and photophobia, which are complemented by reviews of pharmacology and recently discovered novel treatments of the migraine headache. These basic chapters are followed by clinical and genetic information about migraine that provide the links to concepts such as cortical spreading depression (CSD), ion channels, transporters and epilepsy. Exciting recent developments on the migraine mutations discovered and their role in CSD and the role of CSD in aura and trigeminal activation (headache) are also introduced.
This broad approach will be of interest to researchers, clinicians, neurobiologists, neuropharmacologists, neurologists, vascular neurobiologists, and advanced students working on migraine.
