The 2nd edition will be approximately 50% longer than the current edition and will significantly expand coverage of epistasis and mosaic analysis, as well as high-throughput methodologies in yeast. Due to advances in the field, the second edition will also update the coverage of RNAi and include new materials on the use of NextGen Sequencing as a tool for mapping. The new edition will build on the discussion of evolving model systems such as zebra fish and planaria, genetic technology available in the mouse, and the impact of epigenetic phenomena on genetics.