Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels

This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies.

Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels is divided into three logical sections:

• Section One: Neuronal Voltage-Gated Ion Channel Functions

• Section Two: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function

• Section Three: Drug Discovery Targets and Technology

Among the key topics addressed are:

• Biochemical and molecular mechanisms and pathways in neuronal voltage-gated ion channel regulation

• Physiological bases of targeting ion channels in disease

• Advances in screening technologies, and methods for regulating neuronal voltage-gated ion channels

• Custom-developed technologies for ion channel drug discovery

• Utility of neuronal voltage-gated ion channel targets for the development of new medicines in traditional and emerging therapeutic areas

Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study.