Gene Discovery for Disease Models

The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated progress in the positional cloning of genes from mutated models. Gene Discovery for Disease Models provides readers with a comprehensive understanding of the new concepts and protocols implemented in gene discovery in the present post-genome era.

Backed by sound scientific findings, this informative guide not only provides a systematic introduction to the available resources and technologies for gene discovery but, most importantly, teaches readers how to use all the available tools and data to find new mutated genes. Its comprehensive coverage:

• Provides a detailed description of positional cloning and genomic cloning

• Identifies genes of human disease and animal models

• Suggests new paradigms for mutation discovery in the post-genome era

• Describes new concepts in gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest

Gene Discovery for Disease Models helps researchers to not only understand the current concepts and technologies, but also learn how to take advantage of these new resources and technologies in the future and adapt to emerging new discoveries in the genetic sciences. This book can be used as a handbook for gene cloning and discovery, as well as a reference book for teachers and students in the fields of genetics and biology.